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Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

Published: Jan 10th, 2020

Bibtex

Authors

Huang X, LeDuc RD, Fornelli L, Schunter AJ, Bennett RL, Kelleher NL, Licht JD.

Date of Publishing

August 16, 2019

Journal Title

J Biol chem

Volume

294

Number

Number: 33

Pages

12459-12471

Abstract

DOI Number

10.1074/jbc.RA118.006159

URL

https://www.ncbi.nlm.nih.gov/pubmed/31248990

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver

Published: Jan 7th, 2020

Bibtex

Authors

Bennett RL, Bele A, Small EC, Will CM, Nabet B, Oyer JA, Huang X, Ghosh RP, Grzybowski AT, Yu T, Zhang Q, Riva A, Lele TP, Schatz GC, Kelleher NL, Ruthenburg AJ, Liphardt J, Licht JD.

Date of Publishing

October 1, 2019

Journal Title

Cancer Discovery

Volume

9

Number

Number: 10

Pages

1438-1451

Abstract

DOI Number

10.1158/2159-8290

URL

https://cancerdiscovery.aacrjournals.org/content/9/10/1438.long

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.

Published: Sep 8th, 2018

Bibtex

Authors

Swaroop A, Oyer JA, Will CM, Huang X, Yu W, Troche C, Bulic M, Durham BH, Wen QJ, Crispino JD, MacKerell AD Jr, Bennett RL, Kelleher NL, Licht JD.

Date of Publishing

August 31, 2018

Journal Title

Oncogene

Volume

Number

Pages

Abstract

DOI Number

10.1038/s41388-018-0474-y

URL

From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma

Published: Apr 11th, 2017

Bibtex

Licht2014

Authors

Licht, JD; Shortt, J; Johnstone, R.

Date of Publishing

January 13, 2014

Journal Title

Cancer Cell

Volume

25

Number

Number: 1

Pages

9-11

Abstract

DOI Number

10.1016/j.ccr.2013.12.019

URL

https://www.ncbi.nlm.nih.gov/pubmed/24434206

Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity

Published: Apr 11th, 2017

Bibtex

Small2014

Authors

Small, EC; Xi, L; Wang, JP; Widom, J; Licht, JD.

Date of Publishing

June 17, 2014

Journal Title

Proc Natl Acad Sci USA

Volume

111

Number

Number: 24

Pages

E2462-E2471

Abstract

DOI Number

10.1073/pnas.1400517111

URL

https://www.ncbi.nlm.nih.gov/pubmed/24889621

Promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes

Published: Apr 11th, 2017

Bibtex

Choi2014

Authors

Choi, WI; Yoon, JH; Kim, MY; Koh, DI; Licht, JD; Kim, K; Hur Choi, MW.

Date of Publishing

July 4, 2014

Journal Title

J Biol Chem

Volume

289

Number

Number: 27

Pages

18641-18656

Abstract

DOI Number

10.1074/jbc.M113.538777

URL

https://www.ncbi.nlm.nih.gov/pubmed/24821728

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

Published: Apr 11th, 2017

Bibtex

Popovic2014

Authors

Popovic, R; Martinez-Garcia, E; Giannopoulou, EG; Zhang, Q; Ezponda, T; Shah, MY; Zheng, Y; Will, CM; Small, EC; Hua, Y; Bulic, M; Jiang, Y; Carrara, M; Calogero, RA; Kath, WL; Keller, NL; Wang, JP; Elemento, O; Licht, JD.

Date of Publishing

September 4, 2014

Journal Title

PLoS Genet

Volume

10

Number

Number: 9

Pages

e1004566

Abstract

DOI Number

10.1371/journal.pgen.1004566

URL

https://www.ncbi.nlm.nih.gov/pubmed/25188243

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination

Published: Apr 11th, 2017

Bibtex

Ezponda2014

Authors

Ezponda, T; Licht, JD.

Date of Publishing

October 1, 2014

Journal Title

Clin Cancer Res

Volume

20

Number

Number: 19

Pages

5001-5008

Abstract

DOI Number

10.1158/1078-0432.CCR-13-2499

URL

https://www.ncbi.nlm.nih.gov/pubmed/24987060

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

Published: Apr 11th, 2017

Bibtex

Rampal2014

Authors

Rampal, R; Alkalin, A; Madzo, J; Vasanthakumar, A; Pronier, E; Patel, J; Li, Y; Ahn, J; Abdel-Wahab, O; Shih, A; Lu, C; Ward, PS; Tsai, JJ; Hricik, T; Tosello, V; Tallman, JE; Zhao, X; Daniels, D; Dai, Ciminio, L; Aifantis, I; He, C; Fuks, F; Tallman, MS; Ferrando, A; Nimer, S; Paietta, E; Thompson, CB; Licht, JD; Mason, CE; Godley, LA; Melnick, A; Figueroa, ME; Levine, RL.

Date of Publishing

December 11, 2014

Journal Title

Cell Rep

Volume

9

Number

Number: 5

Pages

1841-55

Abstract

DOI Number

10.1016/j.celrep.2014.11.004

URL

https://www.ncbi.nlm.nih.gov/pubmed/25482556

Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation

Published: Apr 11th, 2017

Bibtex

Zhou2015

Authors

Zhou, Z; Gao, J; Popovic, R; Wolniak, K; Parimi; Winter, JN; Licht, JD; Chen, YH.

Date of Publishing

March 8, 2015

Journal Title

Leuk Lymphoma

Volume

56

Number

Number: 10

Pages

2895-2901

Abstract

DOI Number

10.3109/10428194.2015.1006220

URL

https://www.ncbi.nlm.nih.gov/pubmed/25651430