Journal club 3/27
CRISPR-Cas9–guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells…
CRISPR-Cas9–guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells…
We study how mutations in epigenetic regulators lead to wide-ranging defects in gene regulation and the development of blood and other malignancies.
Neri F et al., Intragenic DNA methylation prevents spurious transcription initiation. Nature, 2017.
“Transcription control by the ENL YEATS domain in acute leukaemia”, Erb et al, Nature 2017…
Activation of proto-oncogenes by disruption of chromosome neighborhoods…
H3K4 aceylation and methylation dynamics define breast cancer subtypes…
WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition…
Paper for 1/17 journal club: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape…
Paper for 1/3/17 journal club: High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities…