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Journal club 3/27

CRISPR-Cas9–guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells…

Welcome to the Licht Lab!

We study how mutations in epigenetic regulators lead to wide-ranging defects in gene regulation and the development of blood and other malignancies.

Journal Club 3/21

Neri F et al., Intragenic DNA methylation prevents spurious transcription initiation. Nature, 2017.

Journal Club 3/14

“Transcription control by the ENL YEATS domain in acute leukaemia”, Erb et al, Nature 2017…

Journal club 2/15

Activation of proto-oncogenes by disruption of chromosome neighborhoods…

Journal club 1/31

H3K4 aceylation and methylation dynamics define breast cancer subtypes…

Journal club 1/26

WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition…

Journal club 1/17

Paper for 1/17 journal club: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape…

Journal club 1/3

Paper for 1/3/17 journal club: High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities…