Jixiu Shan

Jixiu Shan, Ph.D.

Associate Scientist

Department: MD-HEMATOLOGY/ONCOLOGY
Business Phone: (352) 392-3364
Business Email: shanjx@ufl.edu

About Jixiu Shan

I earned my Ph.D. from the Chinese Academy of Sciences by studying the biochemical and biophysical mechanisms of photosynthesis. I moved in the United States and studied the protein structure and function as a postdoctoral fellow in Kansas State University. Later I joined Dr. Thomas Yang’s Laboratory in the Department of Biochemistry and Molecular Biology (UF College of Medicine) and studied the genetic and epigenetic molecular mechanisms of mammalian gene imprinting. To continue my endeavor in the study of the molecular mechanism that control mammalian gene expression, I then joined Dr. Michael S. Kilberg’s Laboratory at UF.

I became a member of the Licht laboratory on Aug. 1, 2020. Now I am studying the potential oncogenic functions of histone mutations.

Publications

2023
Histone mutations in cancer.
Biochemical Society transactions. 51(5):1749-1763 [DOI] 10.1042/BST20210567. [PMID] 37721138.
2021
Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a.
PLoS genetics. 17(12) [DOI] 10.1371/journal.pgen.1009934. [PMID] 34914716.
2020
Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability.
Cancers. 12(11) [DOI] 10.3390/cancers12113267. [PMID] 33167336.
2019
Induction of early growth response gene 1 (EGR1) by endoplasmic reticulum stress is mediated by the extracellular regulated kinase (ERK) arm of the MAPK pathways.
Biochimica et biophysica acta. Molecular cell research. 1866(3):371-381 [DOI] 10.1016/j.bbamcr.2018.09.009. [PMID] 30290239.
2018
Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells.
Biochimica et biophysica acta. Gene regulatory mechanisms. 1861(2):72-79 [DOI] 10.1016/j.bbagrm.2018.01.002. [PMID] 29413899.
2016
Influence of Amino Acid Metabolism on Embryonic Stem Cell Function and Differentiation.
Advances in nutrition (Bethesda, Md.). 7(4):780S-9S [DOI] 10.3945/an.115.011031. [PMID] 27422515.
2016
The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation.
Nucleic acids research. 44(20):9719-9732 [PMID] 27471030.
2016
Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress.
Oncotarget. 7(3):3128-43 [DOI] 10.18632/oncotarget.6519. [PMID] 26657730.
2015
Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.
The Journal of biological chemistry. 290(25):15878-15891 [DOI] 10.1074/jbc.M114.635144. [PMID] 25931127.
2015
MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells.
Biochimica et biophysica acta. 1853(3):539-48 [DOI] 10.1016/j.bbamcr.2014.12.013. [PMID] 25523140.
2014
A mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)-dependent transcriptional program controls activation of the early growth response 1 (EGR1) gene during amino acid limitation.
The Journal of biological chemistry. 289(35):24665-79 [DOI] 10.1074/jbc.M114.565028. [PMID] 25028509.
2013
Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells.
American journal of physiology. Endocrinology and metabolism. 305(3):E325-35 [DOI] 10.1152/ajpendo.00136.2013. [PMID] 23736538.
2013
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
Molecular biology of the cell. 24(15):2477-90 [DOI] 10.1091/mbc.E13-01-0067. [PMID] 23761072.
2013
Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation.
The Biochemical journal. 449(1):219-29 [DOI] 10.1042/BJ20120958. [PMID] 22978410.
2013
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
Nature cell biology. 15(5):481-90 [DOI] 10.1038/ncb2738. [PMID] 23624402.
2013
Regulatory elements associated with paternally-expressed genes in the imprinted murine Angelman/Prader-Willi syndrome domain.
PloS one. 8(2) [DOI] 10.1371/journal.pone.0052390. [PMID] 23390487.
2012
ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation.
The Journal of biological chemistry. 287(43):36393-403 [DOI] 10.1074/jbc.M112.399600. [PMID] 22955275.
2012
The transcription factor network associated with the amino acid response in mammalian cells.
Advances in nutrition (Bethesda, Md.). 3(3):295-306 [DOI] 10.3945/an.112.001891. [PMID] 22585903.
2011
Auto-activation of c-JUN gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-JUN-mediated signaling pathway.
The Journal of biological chemistry. 286(42):36724-38 [DOI] 10.1074/jbc.M111.277673. [PMID] 21862593.
2011
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.
Cell death and differentiation. 18(5):769-82 [DOI] 10.1038/cdd.2010.142. [PMID] 21113145.
2010
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells.
Physiological genomics. 41(3):315-27 [DOI] 10.1152/physiolgenomics.00217.2009. [PMID] 20215415.
2009
A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding.
Molecular cancer research : MCR. 7(10):1622-34 [DOI] 10.1158/1541-7786.MCR-09-0018. [PMID] 19825994.
2009
ATF4-dependent transcription mediates signaling of amino acid limitation.
Trends in endocrinology and metabolism: TEM. 20(9):436-43 [DOI] 10.1016/j.tem.2009.05.008. [PMID] 19800252.
2009
Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements.
The Journal of biological chemistry. 284(32):21241-8 [DOI] 10.1074/jbc.M109.011338. [PMID] 19509279.
2008
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells.
The Journal of biological chemistry. 283(41):27736-27747 [DOI] 10.1074/jbc.M803781200. [PMID] 18697751.

Contact Details

Phones:
Business:
(352) 392-3364
Emails:
Business:
shanjx@ufl.edu
Addresses:
Business Mailing:
P.O. Box 100278
PO BOX 100245
Division of Hematology and Oncology
GAINESVILLE FL 32610