Publications » Licht Laboratory » UF Academic Health Center

Venugopal K, Feng Y, Nowialis P, Xu H, Shabashvili DE, Berntsen CM, Kaur P, Krajcik KI, Taragjini C, Zaroogian Z, Casellas Román HL, Posada LM, Gunaratne C, Li J, Dupéré-Richer D, Bennett RL, Pondugula S, Riva A, Cogle CR, Opavsky R, Law BK, Bhaduri-McIntosh S, Kubicek S, Staber PB, Licht JD, Bird JE, Guryanova OA

Clin Cancer Res, 28(4), pp. 756-769, 2022
doi: 10.1158/1078-0432.CCR-21-2863

PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia

Li J, Hlavka-Zhang J, Shrimp JH, Piper C, Dupéré-Richér D, Roth JS, Jing D, Casellas Román HL, Troche C, Swaroop A, Kulis M, Oyer JA, Will CM, Shen M, Riva A, Bennett RL, Ferrando AA, Hall MD, Lock RB, Licht JD

Cancer Discov, 12(1), pp. 186-203, 2022
doi: 10.1158/2159-8290.CD-20-1771

2021 Publications

Targeting epigenetic mechanisms to overcome venetoclax resistance

Prado G, Kaestner CL, Licht JD, Bennett RL

Biochim Biophys Acta Mol Cell Res, 1868(8), 119047, 2021
doi: 10.1016/j.bbamcr.2021.119047

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, Myers RM, Costacurta M, Todorovski I, Pijpers L, Bjelosevic S, Williams T, Huskins SN, Kearney CJ, Devlin JR, Fan Z, Jabbari JS, Martin BP, Fareh M, Kelly MJ, Dupéré-Richer D, Sandow JJ, Feran B, Knight D, Khong T, Spencer A, Harrison SJ, Gregory G, Wickramasinghe VO, Webb AI, Taberlay PC, Bromberg KD, Lai A, Papenfuss AT, Smyth GK, Allan RS, Licht JD, Landau DA, Abdel-Wahab O, Shortt J, Vervoort SJ, Johnstone RW

Mol Cell, 81(10), pp. 2183-2200.e13, 2021
doi: 10.1016/j.molcel.2021.04.015

Leveraging epigenetics to enhance the efficacy of immunotherapy

Licht JD, Bennett RL

Clin Epigenetics, 13(1), pp. 115, 2021
doi: 10.1186/s13148-021-01100-x

2020 Publications

Histone H3 G34 Tail Mutations in Cancer: Actions in Cis and Trans to Alter Chromatin and Gene Expression

Licht JD

Cancer Discov, 10(12), pp. 1794-1796, 2020
doi: 10.1158/2159-8290.CD-20-1396.

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

Ordoñez R, Kulis M, Russiñol N, Chapaprieta V, Carrasco-Leon A, García-Torre B, Charalampopoulou S, Clot G, Beekman R, Meydan C, Duran-Ferrer M, Verdaguer-Dot N, Vilarrasa-Blasi R, Soler-Vila P, Garate L, Miranda E, San José-Enériz E, Rodriguez-Madoz JR, Ezponda T, Martínez-Turrilas R, Vilas-Zornoza A, Lara-Astiaso D, Dupéré-Richer D, Martens JHA, El-Omri H, Taha RY, Calasanz MJ, Paiva B, San Miguel J, Flicek P, Gut I, Melnick A, Mitsiades CS, Licht JD, Campo E, Stunnenberg HG, Agirre X, Prosper F, Martin-Subero JI.

Genome Res, 30(9), pp. 1217-1227, 2020
doi: 10.1101/gr.265520.120

Oncogenesis by E2A-PBX1 in ALL: RUNX and more

Licht JD

Blood, 136(1), pp. 3-4, 2020
doi: 10.1182/blood.2020005879

High-throughput gene screen reveals modulators of nuclear shape

Tamashunas AC, Tocco VJ, Matthews J, Zhang Q, Atanasova KR, Paschall L, Pathak S, Ratnayake R, Stephens AD, Luesch H, Licht JD, Lele TP

Mol Biol Cell, 31(13), pp. 1392-1402, 2020
doi: 10.1091/mbc.E19-09-0520

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

Sheng Y, Yu C, Liu Y, Hu C, Ma R, Lu X, Ji P, Chen J, Mizukawa B, Huang Y, Licht JD, Qian Z

Nat Commun, 11(1), pp. 928, 2020
doi: 10.1038/s41467-020-14590-9

Decitabine limits escape from MEK inhibition in uveal melanoma

Gonçalves J, Emmons MF, Faião-Flores F, Aplin AE, Harbour JW, Licht JD, Wink MR, Smalley KSM

Pigment Cell Melanoma Res, 33(3), pp. 507-514, 2020
doi: 10.1111/pcmr.12849

2019 Publications

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding

Huang X, LeDuc RD, Fornelli L, Schunter AJ, Bennett RL, Kelleher NL, Licht JD

J Biol Chem, 294 (33), pp. 12459-12471, 2019
doi: 10.1074/jbc.RA118.006159

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver

Bennett RL, Bele A, Small EC, Will CM, Nabet B, Oyer JA, Huang X, Ghosh RP, Grzybowski AT, Yu T, Zhang Q, Riva A, Lele TP, Schatz GC, Kelleher NL, Ruthenburg AJ, Liphardt J, Licht JD

Cancer Discov, 9 (10), pp. 1438-1451, 2019
doi: 10.1158/2159-8290

2018 Publications

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.

Swaroop A, Oyer JA, Will CM, Huang X, Yu W, Troche C, Bulic M, Durham BH, Wen QJ, Crispino JD, MacKerell AD Jr, Bennett RL, Kelleher NL, Licht JD

Oncogene, 38, pp. 671-686, 2018
doi: 10.1038/s41388-018-0474-y

2017 Publications

The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer

Bennett RL, Swaroop A, Troche C, Licht JD

Cold Spring Harb Perspect Med, 7(6), a026708, 2017
doi: 10.1101/cshperspect.a026708

2016 Publications

Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases

McConnell MJ, Durand L, Langley E, Coste-Sarguet L, Zelent A, Chomienne C, Kouzarides T, Licht JD, Guidez F

Epigenetics Chromatin, 24(8), pp. 38, 2016
doi: 10.1186/s13072-015-0030-8

Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors

Dupéré-Richer, D; Kinal, M; Pettersson, F; Emond, A; Calvo-Vidal, MN; Nichol, JN; Guilbert, C; Plourde, D; Klein, Oros K; Nielsen, TH; Ezponda, T; Licht, JD; Johnson, NA; Assouline, S; Cerchietti, WH; Miller, Jr, WH; Mann, KK.

Leuk Lymphoma, 58(1), pp. 218-221, 2016
doi: 10.1080/10428194.2016.1180684

H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer

Nichol, JN; Dupéré-Richer, D; Ezponda, T; Licht, JD; Miller, Jr, WH.

Adv Cancer Res, 131 (0), pp. 59-95, 2016
doi: 10.1016/bs.acr.2016.05.001

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

Béguelin, W; Teater, M; Gearhart, MD; Fernández, MT Calvo; Goldstein, RL; Cárdenas, MG; Hatzi, K; Rosen, M; Shen, H; Corcoran, CM; Hamline, MY; Gascoyne, RD; Levine, RL; Abdel-Wahab, O; Licht, JD; Shaknovich, R; Elemento, O; Bardwell, VJ; Melnick, AM.

Cancer Cell, 30 (2), pp. 197-213, 2016
doi: 10.1016/j.ccell.2016.07.006

Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis

Arcipowski, KM; Bulic, M; Gurbuxani, S; Licht, JD.

PLoS One, 11 (9), pp. e0162515, 2016
doi: 10.1371/journal.pone.0162515

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

Shah, MY; Martinez-Garcia, E; Phillip, JM; Chambliss, AB; Popovic, R; Ezponda, T; Small, EC; Will, C; Phillip, MP; Neri, P; Bahlis, NJ; Wirtz, D; Licht, JD.

Oncogene, 35 (45), pp. 5905-5915, 2016
doi: 10.1038/onc.2016.116

Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells

Schauwecker, SM; Kim, JJ; Licht, JD; Clevenger, CV.

J Biol Chem, (0), pp. , 2016
10.1074/jbc.M116.764233

2015 Publications

Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation

Zhou, Z; Gao, J; Popovic, R; Wolniak, K; Parimi; Winter, JN; Licht, JD; Chen, YH.

Leuk Lymphoma, 56 (10), pp. 2895-2901, 2015
doi: 10.3109/10428194.2015.1006220

GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1

Kumar, K; Raza, SS; Knab, LM; Chow, CR; Kwok, B; Bentrem, DJ; Popovic, R; Ebine, K; Licht, JD; Munshi, HG.

Sci Rep, 5 (0), pp. 9489, 2015
doi: 10.1038/srep09489

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression

Zheng, Y; Fornelli, L; Compton, PS, Sharma, S; Canterbury, J; Mullen, C; Zarbroushov, Fellers, RT; Thomas, PM; Licht, JD; Senko, MW; Kelleher, NL.

Mol Cell Proteomics, 15 (3), pp. 776-90, 2015
doi: 10.1074/mcp.M115.053819

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

Nabet, B; Broin, PÓ; Reyes, JM; Shieh, K; Lin CY; Will, CM; Popovic, R; Ezponda, T; Bradner, JE; Golden, AA; Licht, JD.

Cell Rep, 12 (8), pp. 1300-1313, 2015
doi: 10.1016/j.celrep.2015.06.078

DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension

Licht, JD.

Cell, 162 (5), pp. 938-939, 2015
doi: 10.1016/j.cell.2015.08.005

2014 Publications

From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma

Licht, JD; Shortt, J; Johnstone, R.

Cancer Cell, 25 (1), pp. 9-11, 2014
doi: 10.1016/j.ccr.2013.12.019

Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity

Small, EC; Xi, L; Wang, JP; Widom, J; Licht, JD.

Proc Natl Acad Sci USA, 111 (24), pp. E2462-E2471, 2014
doi: 10.1073/pnas.1400517111

Promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes

Choi, WI; Yoon, JH; Kim, MY; Koh, DI; Licht, JD; Kim, K; Hur Choi, MW.

J Biol Chem, 289 (27), pp. 18641-18656, 2014
doi: 10.1074/jbc.M113.538777

Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

Popovic, R; Martinez-Garcia, E; Giannopoulou, EG; Zhang, Q; Ezponda, T; Shah, MY; Zheng, Y; Will, CM; Small, EC; Hua, Y; Bulic, M; Jiang, Y; Carrara, M; Calogero, RA; Kath, WL; Keller, NL; Wang, JP; Elemento, O; Licht, JD.

PLoS Genet, 10 (9), pp. e1004566, 2014
doi: 10.1371/journal.pgen.1004566

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination

Ezponda, T; Licht, JD.

Clin Cancer Res, 20 (19), pp. 5001-5008, 2014
doi: 10.1158/1078-0432.CCR-13-2499

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

Rampal, R; Alkalin, A; Madzo, J; Vasanthakumar, A; Pronier, E; Patel, J; Li, Y; Ahn, J; Abdel-Wahab, O; Shih, A; Lu, C; Ward, PS; Tsai, JJ; Hricik, T; Tosello, V; Tallman, JE; Zhao, X; Daniels, D; Dai, Ciminio, L; Aifantis, I; He, C; Fuks, F; Tallman, MS; Ferrando, A; Nimer, S; Paietta, E; Thompson, CB; Licht, JD; Mason, CE; Godley, LA; Melnick, A; Figueroa, ME; Levine, RL.

Cell Rep, 9 (5), pp. 1841-55, 2014
doi: 10.1016/j.celrep.2014.11.004