2014 Publications


From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma

Licht, JD; Shortt, J; Johnstone, R.

Cancer Cell, 25 (1), pp. 9-11, 2014.
10.1016/j.ccr.2013.12.019
Pubmed https://www.ncbi.nlm.nih.gov/pubmed/24434206



Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity

Small, EC; Xi, L; Wang, JP; Widom, J; Licht, JD.

Proc Natl Acad Sci USA, 111 (24), pp. E2462-E2471, 2014.
10.1073/pnas.1400517111
Pubmed https://www.ncbi.nlm.nih.gov/pubmed/24889621



Promyelocytic leukemia zinc finger-retinoic acid receptor α (PLZF-RARα), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes

Choi, WI; Yoon, JH; Kim, MY; Koh, DI; Licht, JD; Kim, K; Hur Choi, MW.

J Biol Chem, 289 (27), pp. 18641-18656, 2014.
10.1074/jbc.M113.538777
Pubmed https://www.ncbi.nlm.nih.gov/pubmed/24821728



Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation

Popovic, R; Martinez-Garcia, E; Giannopoulou, EG; Zhang, Q; Ezponda, T; Shah, MY; Zheng, Y; Will, CM; Small, EC; Hua, Y; Bulic, M; Jiang, Y; Carrara, M; Calogero, RA; Kath, WL; Keller, NL; Wang, JP; Elemento, O; Licht, JD.

PLoS Genet, 10 (9), pp. e1004566, 2014.
10.1371/journal.pgen.1004566
Pubmed https://www.ncbi.nlm.nih.gov/pubmed/25188243



Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination

Ezponda, T; Licht, JD.

Clin Cancer Res, 20 (19), pp. 5001-5008, 2014.
10.1158/1078-0432.CCR-13-2499
Pubmed https://www.ncbi.nlm.nih.gov/pubmed/24987060



DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

Rampal, R; Alkalin, A; Madzo, J; Vasanthakumar, A; Pronier, E; Patel, J; Li, Y; Ahn, J; Abdel-Wahab, O; Shih, A; Lu, C; Ward, PS; Tsai, JJ; Hricik, T; Tosello, V; Tallman, JE; Zhao, X; Daniels, D; Dai, Ciminio, L; Aifantis, I; He, C; Fuks, F; Tallman, MS; Ferrando, A; Nimer, S; Paietta, E; Thompson, CB; Licht, JD; Mason, CE; Godley, LA; Melnick, A; Figueroa, ME; Levine, RL.

Cell Rep, 9 (5), pp. 1841-55, 2014.
10.1016/j.celrep.2014.11.004
https://www.ncbi.nlm.nih.gov/pubmed/25482556